an ambitious purpose

we support research
in perinatal neurology

EU-BRAIN was created with the aim of strengthening research in the field of perinatal neurology, an area in which research has enormous potential for development.


Eu-Brain promotes and supports innovative research projects aimed at making an important contribution to the understanding of the causes and the research of the treatment of neurological problems in the perinatal field.

Project PIOMI: Premature Infant Oral Motor Intervention
The aim of the project was to help premature children learn how to suck milk well – not so easy for someone who is born early! The parents of the children admitted to the Department of Pathology and Neonatal Intensive Care of the Istituto Giannina Gaslini were taught the oral stimulation technique – so called PIOMI method – so that the parents themselves could become the protagonists of the treatment process. Research results are now being published in international newspapers, while you can find out more by reading our article on the first experiences of parents here.

Oxidative stress as a risk factor for brain damage
The aim of the project was to review the scientific literature on the role of oxidative stress in the development of brain lesions in premature children. You can find here the final full-length article published in the prestigious journal Frontiers in Pediatrics, while in our section dedicated to science bits there is an abstract for the general public.

Early experiences of neonatal brain pain and connectivity
Eubrain has awarded and provided support in the publication of the work dedicated to the role of painful experiences, such as, for example, heel puncture, on brain connectivity in premature children. You can find here the full-length article, published in the journal Frontiers in Neuroscience, whereas here we describe in detail the work done.

Role of placenta in brain hemorrhages in premature children
Support was provided in the publication of the article which sought to uncover possible connections between some placental inflammatory lesions and risk of intracranial bleeding, such as, for example, intraventricular hemorrhage. The full article, published in the journal Frontiers in Neurology, can be consulted here.

Neonatal hypoglycemia and brain vulnerability
The purpose of the article was to review the literature on the relationship between hypoglycemia, or low blood sugar, and brain damage in infants. The full article, published in the journal Frontiers in Endocrinology, can be downloaded from here.

Different forms of targeted white matter lesions in prematures
Eu-Brain has provided support in the implementation of research project dedicated to punctuated injuries of the white matter – or small “specks” that can be found by performing brain MRI in premature babies. In the work it has been tried to describe in detail two types of these lesions, in order to better recognize them and in order to be able to understand their meaning. You will find the full article published in the newspaper Frontiers in Neurology here.

Project “MRI for future”

The purpose of this project is to highlight specific signs present in brain MRI in order to predict future neurological difficulties in premature children. The MRI Images will be analyzed in order to highlight the presence and type of brain lesions, as well as to evaluate brain growth and the degree of maturation achieved, to then be able to compare them with the results of evaluation with the Griffiths scale at 3 years of age, in an attempt to better target rehabilitation interventions.

Neonatal lipidomic: when lipids make the difference
The project aims to identify early lipid markers predictive of the state of maturation of the white substance in premature patients, both with and without brain lesions in order to allow in the future a timely identification of newborns at risk which could therefore benefit from early rehabilitation programs based on multisensorial stimulations.

Each year Eu-Brain awards prizes to young neuroscientists that stand out for their research in prenatal and neonatal neurology. Since 2018, an award is awarded as part of the congress Agorà SIMP (Italian Society of Perinatal Medicine) and three awards at the BraYn conference (Brainstorming Research Assembly for Young Neuroscientists).

BraYn 2018 Marina Boido wins the special award Eu-Brain with the research “Increasing agrin function antagonizes muscle atrophy and motor impairment in a murine model of SMA”. Read more
SIMP 2018 Carlo Di Biase wins the Eu-Brain award with the research Precocious experiences of neonatal brain pain and connectivity – SIMP Congress – EUBRAIN.Read more.

BraYn 2019 vince il premio della neonata sezione ‘perinatal neurology’ Sara De Crescenzo con la ricerca “Growth parameters and minor brain lesions in vlbw newborns as prognostic factors of negative neurodevopmental outocome at two and three years of age”

SIMP 2019 Sara De Crescenzo wins the prize of the newly created section of Perinatal neurology with research “Growth parameters and minor brain lesions in vlbw newborns as prognostic factors of negative neurodevopmental outocome at two and three years of age”

SIMP 2019
Sara De Crescenzo wins the Eu-Brain award with research ‘Minor brain lesions and auxological data in very low preterm newborns (VLBW) as prognostic factors of negative neurodevelopmental outcome at two and three years of age.

BraYn 2020 De Rosa Roberta (in photo) perinatal neurology award, abstract title ‘A novel role of CDKL5 at inhibitory synapses and a possible therapeutic strategy for CDKL5 related defects.

BraYn 2021 to Carpenter Jenna and her study on “Progressive myoclonus epilepsy KCNC1 (KV3.1) variant causes a developmental dendritopathy” the award is named in memory of Pino De Gioia, a man of great generosity, husband and father

Starting from the school year 2021/22 we want to establish a university scholarship for researchers. In fact, Eu-Brain intends to enhance potential excellence, supporting talents and providing resources to conduct studies in the most promising fields of research.

The registers are a very useful tool for researchers and clinicians, because they allow, through a systematic collection of personal, clinical and health data, to have a better knowledge of different diseases or to define standards of care.

Study project “RIPENSA”
Eu-Brain intends to promote the construction of the national registry for hypoxic-ischemic encephalopathy, which affects more than one in a thousand children every year. The RIPENSA Registry, acronym of the “Italian Perinatal Registry for post-SfitticA Encephalopathy”, is a flagship project of the research program supported by Eu-Brain; Birth centers throughout the country will be involved to RETHINK neonatal asphyxiation, an event that can occur anywhere, with the aim of being united to face this challenge. The register will be updated in a systematic way and will provide accurate data on incidence, risk factors and methods of treatment of hypoxic-ischemic encephalopathy, with the aim of prevention, care and monitoring, creating the basis for further scientific research, and in particular for the development of clinical and epidemiological studies.

Eu-Brain supports research centers by purchasing state-of-the-art machinery and research tools.

“Griffiths III” Scale 
for the evaluation
of psychomotor development

Ultrasound of the latest generation
to perform brain ultrasound
to premature children

State-of-the-art sensor to perform
blood sugar levels in hospitalized premature infants

EEG monitoring system
with the possibility of video recording
with a night sensor

The organization of events for researchers and clinicians is an important opportunity for discussion and exchange and encourages the development of collaborations between national and international research groups on new directions to explore. Eu-Brain organizes meetings aimed at the scientific community on topics of interest related to the perinatal area, inviting representatives of the Clinical Centers of reference and involving Italian and foreign speakers.

at the side of families

Spreading the perinatal neurological culture

Una migliore conoscenza delle possibili complicanze legate a una nascita prematura o degli imprevisti che possono insorgere con una nascita a termine aiuta a gestire in modo più consapevole e informato le inevitabili difficoltà e a diminuire l’impatto negativo su tutto il nucleo famigliare.

Eu-Brain fornisce informazioni a cui tutti possono accedere.

«What is a transfontanellar ultrasound? What does my child see? » Eu-Brain devotes commitment and resources to sharing «bits» of science with parents so that even the most complex information can be understood by «non-professionals». The blog combines scientific accuracy with a popular language to explain how the brain of infants works, which problems it can encounter in the period around birth, what progress has been made in research and what is new in the field of diagnosis and treatment.
Eu-Brain organizes online training events aimed at the general public to spread in an accessible way the information related to neurological problems that may arise in the prenatal period and immediately after birth. The information initiatives offer targeted opportunities for discussion with experts, providing for the active involvement of the participants.
Eu-Brain makes use of a pediatrician with knowledge of perinatal neurology that responds to requests for clarification posed by the family by providing information, outlining possible solutions and directing the family to the services and the relevant contacts.


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